Tacos and Tech Podcast
Neal Bloom
Podcast
Episodes
Listen, download, subscribe
From Operator to Fund Manager
Episode Summary Neal sits down with Will Alaynick, managing partner at Phase Two Ventures, for a fireside chat on what it actually looks like to go from building a company to running a venture fund. Will walks through his journey from operating a life science instrumentation startup - backed by a strategic investor who gave him governance, talent, and manufacturing access - to raising a fund focused on the tools and infrastructure layer of biotech. They dig into how fund managers evaluate deals differently than angels, why SBIR funding can be a double-edged sword, and what it takes to say no for a living. Key Topics * How a strategic investor provided governance, talent, and manufacturing - not just capital * Building Phase Two Ventures from operator pattern recognition * Evaluating life science deals through the lens of an ex-founder * SBIR funding as a signal - and when it becomes a distraction * The difference between angel deal evaluation and fund-level portfolio construction * Why most of the venture job is saying no - and how to do it humanely * AI's emerging role in life science - and why wet labs still matter * What angels should know before making the leap to managing a fund Links & Resources * Phase Two Ventures * San Diego Angel Conference * Rising Tide Partners Connect on LinkedIn * Will Alaynick * Neal Bloom This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit risingtidepartners.substack.com/subscribe
Tacos and Tech Podcast RSS Feed
